Check the Windows Defender Configuration and Settings:

Get-MpPreference

Turn off Windows Defender Real-Time Protection using PowerShell

Set-MpPreference -DisableRealtimeMonitoring $true

Turn onWindows Defender Real-Time Protection using PowerShell

Set-MpPreference -DisableRealtimeMonitoring $false

Add a File path exclusion:

Set-MpPreference -ExclusionPath "C:\temp", "C:\VM", "C:\NanoServer"

Add process exclusion

Set-MpPreference -ExclusionProcess "vmms.exe", "Vmwp.exe"

To remove windows defender open command prompt with administrator and copy following

Dism /online /Disable-Feature /FeatureName:Windows-Defender /Remove /NoRestart /quiet

restart server

Get-MpPreference